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SPONSORS OF AGE
2001 |
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Our major underwriters are:
Janssen Pharmaceutica Inc.
Glenn Foundation for Medical Research
Pfizer, Inc.
Our co-sponsors include:
Geron Corporation
The Institute for the Study of Aging, Inc.
The Kronos Longevity Research Institute
Michael Fossel, MD, PhD
Aventis Pharmaceuticals
Wild Blueberry Association of North America
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PROGRAM COMMITTEE
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Judd Aiken, PhD
University of Wisconsin
Madison, WI
Arthur K. Balin, MD, PhD
The Sally Balin Medical Ctr.
Media, PA
Roger McCarter, PhD
University of Texas Health Science Center
San Antonio, TX
Vincent Cristofalo, PhD
Lankenau Medical Res. Ctr.
Wynnewood, PA
Donald K. Ingram, PhD
National Institute on Aging
Baltimore, MD
Mark A. Lane, PhD
National Institute on Aging
Baltimore, MD
Mohsen Meydani, DVM, PhD
USDA/HNRCA, Tufts University
Boston, MA
Richard Weindruch, PhD
University of Wisconsin
Madison, WI
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Successful Aging:
Exploring Interventions for Maximizing Lifespan and Healthspan
American Aging Association
30th Annual Meeting
American College of Clinical Gerontology
15th Annual Meeting
American Federation for Aging Research
14th Annual Grantee Conference
June 1-4, 2001
Monona Terrace Convention Center
Madison, Wisconsin
Thursday, May 31 and Friday, June 1, 2001: preconference workshop
Nonhuman Primate Models of Aging:
Evaluating their Current Status and Future Potential
Organizers:
Joseph Kemnitz, Ph.D., Wisconsin Regional Primate Research
Center
Donald Ingram, Ph.D., National Institute on Aging
Thursday, May 31, Afternoon Session: Nonrhesus Species
Chairs: Joseph Kemnitz, Ph.D., Wisconsin Regional Primate Research Center, and Donald Ingram, Ph.D., National Institute on Aging
1:00 p.m. Joseph Erwin, Ph.D., Bioqual, Inc.
The Evolution of Longevity in Primates
1:30 p.m. John Allman, California Institute of Technology
Brain Aging in Mouse Lemurs
2:00 p.m. David H. Abbott, Ph.D., Wisconsin Regional Primate Research Center
Common marmosets (Callithrix jacchus) provide an alternative to macaques as nonhuman primate models of aging
2:30 p.m. Lawrence Williams, University of South Alabama College of Medicine
Captive Squirrel Monkey Demographics and Implications for Aging
3:00 p.m. Break
3:30 p.m. Mary Lou Voytko, Ph.D., Wake Forest University School of Medicine
The Cynomolgus Monkey as a Model of Aging
4:00 p.m. Michael Mahaney, Ph.D., Southwest Regional Primate Research Center
Finding Genes for Complex, Age-Related Changes in Nonhuman Primates: The Pedigreed Baboon Model
4.30 p.m. James Herndon, Ph.D., Yerkes Regional Primate Research Center
Is the Chimpanzee a Practical Model of Human Aging?
5:00 p.m. Adjourn
6:30 p.m. Group Dinner
Thursday, May 31, Evening Session
Chair: George Roth, Ph.D., National Institute on Aging
7:30 p.m. Joseph Kemnitz, Ph.D., Wisconsin Regional Primate Research Center
Dietary Restriction and Aging in Rhesus Monkeys: The University of Wisconsin Project
8:00 p.m. Donald Ingram, Ph.D., National Institute on Aging
Overview of the NIA Aging Rhesus Monkey Project
8:30 p.m. Mark Lane, Ph.D., National Institute on Aging
The Primate Aging Database (PAD)
Friday, June 1, Morning Session: Rhesus Monkeys
(Macaca mulatta): General Systems
Chairs: Mary Lou Voytko, Wake Forest University School of Medicine
8:00 a.m. Robert R. Freedman, Ph.D., Wayne State University School of Medicine
Physiological Mechanisms and Potential for a Primate Model
8:30 a.m. Ricki Colman, Ph.D., Wisconsin Regional Primate Research Center
Skeletal Effects of Aging, Menopause and Dietary Restriction in Rhesus Macaques
9:00 a.m. William Cefalu, M.D., University of Vermont College of Medicine
Model of Cardiovascular Aging in Macaca Fascicularis and Macaca Mulatta
9:30 a.m. Barbara Hansen, Ph.D., University of Maryland School of Medicine
Natural History of Metabolic Syndrome X in Rhesus Monkeys
10:30 a.m. Terry D. Oberley, M.D., Ph.D., University of Wisconsin Medical School
Oxidative Aging in Rhesus Monkey Skeletal Muscle
11:00 a.m. Judd Aiken, Ph.D., University of Wisconsin
Mitochondrial DNA Abnormalities and Fiber Atrophy in Rhesus Monkey Skeletal Muscle
11:30 a.m. Mary Ann Croft and B'Ann Gabelt, M.S., Wisconsin Regional Primate Research Center
Effects of Aging on Lens and Ciliary Muscle Function and Aqueous Humor Dynamics
Friday, June 1, Afternoon Session: Rhesus Monkeys
(Macaca mulatta): Brain and Behavior
Chairs: Judd Aiken, Ph.D., University of Wisconsin, and Barbara Hansen, Ph.D., University of Maryland School of Medicine
1:00 p.m. Patrick Hof, M.D., Mt. Sinai School of Medicine
Neuropsychology of Cognitive Aging in the Rhesus Monkey
1:30 p.m. Mark Moss, Boston University School of Medicine
The Aging Rhesus Monkey: Patterns of Cognitive Impairment in Normal Aging and Cerebrovascular Disease
2:00 p.m. Douglas Rosene, Ph.D., Boston University School of Medicine
The Aging Rhesus Monkey: Patterns of Neurobiological Change in Successful and Unsuccessful Aging
2:30 p.m. Jerry Buccafusco, Ph.D., Medical College of Georgia
Pharmacological Manipulation of Memory Performance in Aged Monkeys
3:00 p.m. Break
3:30 p.m. Steven Kohama, Ph.D., Oregon Regional Primate Research Center
Neurochemical and Neuroendocrine Alterations in the Aged Rhesus Brain: A Review
4:00 p.m. Don Gash, Ph.D., University of Kentucky College of Medicine
Rhesus Monkeys Model the Age-Related Motoric Declines and Expression of Parkinsonian Features of Human Senescence
4:30 p.m. Clive Svendsen, Ph.D., University of Wisconsin-Madison
Stem Cell Therapy and Aging
5:00 p.m. Judith Corr, Ph.D., Ohio State University
Social Aging in Free-Ranging Rhesus Macaques
5:30 p.m. Adjourn
6:30 p.m. Poster Session including Demonstration of the Primate Aging Database (PAD)
Friday, June 1 through Monday, June 4, 2001: annual meeting
Friday, June 1, 2001
Registration
5:00 - 6:00 Registration
6:00 - 8:00 Welcome reception and special poster session:
"Caloric Restriction in Nonhuman Primates"
Saturday, June 2, 2001
8:00 - 8:15 Opening Remarks
Hormone Replacement Therapy in Animal Models
Chair: Andrzej Bartke, Ph.D.
8:15 - 8:45 " Endocrine Function in Long Living Mouse Mutants: The Other Side of the Coin"
Andrzej Bartke, Ph.D., Dept. of Physiology, Southern Illinois University, Carbondale, IL
8:45 - 9:15 " Androgen Effects on Bone and Body Composition"
Dirk Vanderschueren, M.D., Ph.D., Laboratory for Experimental Medicine and Endocrinology, Catholic University, Leuven, Belgium
9:15 - 9:45 " The Effects of Selective Estrogen Receptor Modulators in Bone"
Thomas A. Brown, Ph.D., Pfizer, Inc., Dept. of Cardiovascular and Metabolic Diseases, Groton, CT
9:45 - 10:00 BREAK
Hormone Replacement Therapy in Animal Models
Chair: S. Mitchell Harman, M.D., Ph.D.
10:00 - 10:30 " Effects of GH and Sex Steroid Replacement in Healthy Women and Men over 65 Years of Age"
S. Mitchell Harman, M.D., Ph.D., Research Director, Kronos Foundation, Phoenix, AZ
10:30 - 11:00 "Testosterone and Aging-Associated Sarcopenia"
Shallendar Bhasin, M.D., Professor, Dept. of Medicine and Chief, Division of Endocrinology, Metabolism, and Molecular Medicine, Charles Drew University, Los Angeles, CA
11:00 - 11:30 " Estrogen and Cognitive Functioning in Postmenopausal Women: Evidence from Clinical Studies"
Barbara Sherwin, Ph.D., Professor, Departments of Psychology and Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada
11:30 - 12:00 " Ghrelin and the GHRP Analogues, Pharmacology, Actions, and Promise for Hormone Replacement in the Elderly"
Roy Smith, Ph.D., Professor and Director, Huffington Center on Aging, Baylor College of Medicine, Houston, TX
12:00 - 12:30 " Pros and Cons of Estrogen/Progestin Replacement in Postmenopausal Women: What the Current Evidence Means"
Jan L. Shifren, M.D., Harvard Medical School, Massachusetts General Hospital, Boston, MA
12:30 - 2:00 LUNCH (on your own)
2:00 - 3:00
Irving Wright Lecture (Annual AFAR Award Lecture)
"Exercise Deficiency and Secondary Aging: The abdominal Obesity Syndrome"
John Holloszy, M.D., Washington University, St Louis, MO
3:00 - 3:15 BREAK
3:15 - 5:30 Submitted paper session (Chair: Mark A. Lane, Ph.D.)
" GONADAL HORMONES CONTROL BRAIN LEVELS OF ALZHEIMER'S BETA-AMYLOID IN ANIMALS AND PLASMA BETA-AMYLOID LEVELS IN HUMANS"
S. Gandy
" A CLINICALLY APPLIED DOSE OF (-)DEPRENYL CAN INCREASE ANTIOXIDANT ENZYME ACTIVITIES IN BRAIN AS WELL AS EXTRA-BRAIN TISSUES IN MONKEYS"
K. Kitani
" CALORIC RESTRICTION AND ITS INFLUENCE ON GLYCOLYSIS"
K. Hagopian
" AN IN VITRO MODEL OF ENHANCED STRESS RESPONSIVENESS BY CALORIC RESTRICTION: A NOVEL METHOD FOR EVALUATION OF POSSIBLE MECHANISMS AND CANDIDATE CALORIC RESTRICTION MIMETICS"
R. de Cabo
" SELECTION FOR REDUCED FEEDING IN LARVAE OF DROSOPHILA MELANOGASTER MIMICS THE DIETARY RESTRICTION EFFECT"
L. S. Luckinbill
" MECHANISMS OF AGING IN LENS CELLS, RELATION TO CATARACT"
Norman Wolf
6:00 - 8:00 Annual AGE Board of Directors Meeting
Sunday, June 3, 2001
Using Gene Targeting and Transgenics to Probe Aging Processes
Chair: James Nelson, Ph.D.
8:00 - 8:30 " Probing the Role of Glucocorticoids in Aging and Calorie Restriction Using Mice with a Targeted Disruption of the CRH Gene"
James Nelson, Ph.D., University of Texas Health Science Center at San Antonio
8:30 - 9:00 " Knockout and Transgenic Mouse Models to Define the Role of Oxidative Stress in Aging"
Holly Van Remmen, Ph.D., University of Texas Health Science Center at San Antonio
9:00 - 9:30 " Musculoskeletal Aging in Transgenic Mice Overexpressing hsp70"
Anne McArdle, Ph.D., Muscle Research Centre, Department of Medicine, University of Liverpool, UK
9:30 -10:00 " Loss of Leptin Sensitivity in Aging Hyperleptinemic Transgenic Mice"
Farid Chehab, Ph.D., Dept. of Laboratory Medicine, University of California San Francisco
10:00 -10:30 BREAK
Neural Stem Cells and the Aging Brain
Chair: Mark P. Mattson, Ph.D.
10:30 -11:00 " Molecular Mechanisms Regulating Stem Cell Differentiation"
Yi Sun, Ph.D., Dept. of Neurology, Children's Hospital and Harvard University, Boston, MA
11:00 -11:30 " Stem Cell Genetics and Aging"
Gary Van Zant, Ph.D., University of Kentucky, Lexington, KY
11:30 -12:00 " Neurogenesis in the Aging Brain"
Gerd Kempermann, M.D., Ph.D. University of Regensberg, Regensberg, Germany
12:00 -12:30 " Effects of Aging and Calorie Restriction on Neural Stem Cells"
Mark P. Mattson, Ph.D., National Institute on Aging, Baltimore, MD
12:30 - 2:00 LUNCH (on your own)
2:00 - 3:00
Annual Hayflick Award Lecture
"Telomeres and Their Role in Replicative Aging and Cancer"
Woodring Wright, M.D., Ph.D., University of Texas Southwestern Medical Center at Dallas, TX
3:00 - 3:15 BREAK
The Role of Exercise in Successful Aging
Chairs: John Holloszy, M.D. and Li Li Ji, Ph.D.
3:15 - 3:45 " Effect of Exercise on Longevity"
John Holloszy, M.D., Washington University, St Louis, MO
3:45 - 4:15 " Prevention and Treatment of Type II Diabetes with Exercise"
Loretta DiPietro, Ph.D., John B. Pierce Laboratories, Yale University School of Medicine, New Haven, CT
4:15 - 4:45 "
Strength Training in the Prevention and Treatment of Frailty in the Elderly"
William Evans, Ph.D., Donald W. Reynolds Center on Aging, University of Arkansas Medical School, Little Rock, AR
4:45 - 5:15 " Exercise and Oxidative Stress During Aging"
Li Li Ji, Ph.D., University of Wisconsin, Madison, WI
5:30 - 6:00 AGE Business Meeting
6:00 - 8:30 Poster Session
Those presenting posters, please note that poster boards will be 8 feet wide by 4 feet high.
Monday, June 4, 2001
Caloric Restriction Mimetics
Chair: George Roth, Ph.D.
8:00 - 8:30 " Beneficial Effects of Calorie Restriction Mimetic Dietary Supplements: A Cell Stress-Based Mechanism"
Mark P. Mattson, Ph.D., National Institute on Aging, Baltimore, MD
8:30 - 9:00 " CR and Non-Metabolizable Glucose Analogs Stimulate Growth Factor Production in the Brain"
Wenzhen Duan, Ph.D., National Institute on Aging, Baltimore, MD
9:00 - 9:30 " Caloric Restriction and CR Mimetics: Possible Relevance to Humans"
George Roth, Ph.D., Gerotech, Inc. and National Institute on Aging, Baltimore, MD
9:30 - 10:00 " DNA Microarrays as a Screening Tool for CR Mimetic Interventions"
Richard Weindruch, Ph.D., University of Wisconsin, Madison, WI
10:00 - 10:20 BREAK
Nutritional Interventions in Neurobiological Aging
Chairs: Barbara Shukitt-Hale, Ph.D. and James Joseph, Ph.D.
10:20 - 10:50 " The Effect of Dietary and Micro- and Macronutrients on Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease"
David G. Morgan, Ph.D., Univ. of South Florida, Tampa, FL
10:50 - 11:20 " Neuroprotective Strategies with Antioxidant Nutrients and Novel Neuroprotective Drugs in Progressive Neurodegenerative Diseases"
Moussa Youdim, Ph.D., Eve Topf and National Parkinson's Foundation Centers of Excellence for Neurodegenerative Diseases Research, Haifa, Israel
11:20 -11:50 " Natural Products as Blockers of Amyloid's Toxicity: Relevance to Alzheimer's Disease"
Remi Quirion, Ph.D., Dept. of Psychiatry, Douglas Hospital Research Center, Quebec, Canada
11:50 -12:20 " The Antioxidant and Anti-inflammatory Effects of Blueberries on Age-sensitive Tests of Behavior and Brain Function"
Barbara Shukitt-Hale, Ph.D., USDA, HNRC on Aging at Tufts University, Boston, MA
12:15 - 2:00 Annual Award Luncheon
2:00 - 3:00
Denham Harman Award Lecture
"The Use of Transgenic/Knockout Mice to Study the Free Radical Theory of Aging"
Arlan Richardson, Ph.D., University of Texas Health Science Center at San Antonio
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