Thursday, May 31 and Friday, June 1, 2001: preconference workshop

Nonhuman Primate Models of Aging: Evaluating their Current Status and Future Potential

Organizers:
Joseph Kemnitz, Ph.D., Wisconsin Regional Primate Research Center
Donald Ingram, Ph.D., National Institute on Aging

Thursday, May 31, Afternoon Session: Nonrhesus Species

Thursday, May 31, Evening Session

Friday, June 1, Morning Session: Rhesus Monkeys (Macaca mulatta): General Systems

Friday, June 1, Afternoon Session: Rhesus Monkeys (Macaca mulatta): Brain and Behavior

Friday, June 1 through Monday, June 4, 2001: annual meeting

Friday, June 1, 2001

Registration

5:00 - 6:00 Registration

6:00 - 8:00 Welcome reception and special poster session: "Caloric Restriction in Nonhuman Primates"

TOP

Saturday, June 2, 2001

8:00 - 8:15 Opening Remarks

Hormone Replacement Therapy in Animal Models

Chair: Andrzej Bartke, Ph.D.

8:15 - 8:45 "Endocrine Function in Long Living Mouse Mutants: The Other Side of the Coin"

Andrzej Bartke, Ph.D., Dept. of Physiology, Southern Illinois University, Carbondale, IL

8:45 - 9:15 "Androgen Effects on Bone and Body Composition"

Dirk Vanderschueren, M.D., Ph.D., Laboratory for Experimental Medicine and Endocrinology, Catholic University, Leuven, Belgium

9:15 - 9:45 "The Effects of Selective Estrogen Receptor Modulators in Bone"

Thomas A. Brown, Ph.D., Pfizer, Inc., Dept. of Cardiovascular and Metabolic Diseases, Groton, CT

9:45 - 10:00 BREAK

Hormone Replacement Therapy in Animal Models

Chair: S. Mitchell Harman, M.D., Ph.D.

10:00 - 10:30 "Effects of GH and Sex Steroid Replacement in Healthy Women and Men over 65 Years of Age"

S. Mitchell Harman, M.D., Ph.D., Research Director, Kronos Foundation, Phoenix, AZ

10:30 - 11:00 "Testosterone and Aging-Associated Sarcopenia"

Shallendar Bhasin, M.D., Professor, Dept. of Medicine and Chief, Division of Endocrinology, Metabolism, and Molecular Medicine, Charles Drew University, Los Angeles, CA

11:00 - 11:30 "Estrogen and Cognitive Functioning in Postmenopausal Women: Evidence from Clinical Studies"

Barbara Sherwin, Ph.D., Professor, Departments of Psychology and Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada

11:30 - 12:00 "Ghrelin and the GHRP Analogues, Pharmacology, Actions, and Promise for Hormone Replacement in the Elderly"

Roy Smith, Ph.D., Professor and Director, Huffington Center on Aging, Baylor College of Medicine, Houston, TX

12:00 - 12:30 "Pros and Cons of Estrogen/Progestin Replacement in Postmenopausal Women: What the Current Evidence Means"

Jan L. Shifren, M.D., Harvard Medical School, Massachusetts General Hospital, Boston, MA

12:30 - 2:00 LUNCH (on your own)

2:00 - 3:00 Irving Wright Lecture (Annual AFAR Award Lecture)

John Holloszy, M.D., Washington University, St Louis, MO

3:00 - 3:15 BREAK

3:15 - 5:30 Submitted paper session (Chair: Mark A. Lane, Ph.D.)

"GONADAL HORMONES CONTROL BRAIN LEVELS OF ALZHEIMER'S BETA-AMYLOID IN ANIMALS AND PLASMA BETA-AMYLOID LEVELS IN HUMANS"

S. Gandy

"A CLINICALLY APPLIED DOSE OF (-)DEPRENYL CAN INCREASE ANTIOXIDANT ENZYME ACTIVITIES IN BRAIN AS WELL AS EXTRA-BRAIN TISSUES IN MONKEYS"

K. Kitani

"CALORIC RESTRICTION AND ITS INFLUENCE ON GLYCOLYSIS"

K. Hagopian

"AN IN VITRO MODEL OF ENHANCED STRESS RESPONSIVENESS BY CALORIC RESTRICTION: A NOVEL METHOD FOR EVALUATION OF POSSIBLE MECHANISMS AND CANDIDATE CALORIC RESTRICTION MIMETICS"

R. de Cabo

"SELECTION FOR REDUCED FEEDING IN LARVAE OF DROSOPHILA MELANOGASTER MIMICS THE DIETARY RESTRICTION EFFECT"

L. S. Luckinbill

"MECHANISMS OF AGING IN LENS CELLS, RELATION TO CATARACT"

Norman Wolf

6:00 - 8:00 Annual AGE Board of Directors Meeting

TOP

Sunday, June 3, 2001

Using Gene Targeting and Transgenics to Probe Aging Processes

Chair: James Nelson, Ph.D.

8:00 - 8:30 "Probing the Role of Glucocorticoids in Aging and Calorie Restriction Using Mice with a Targeted Disruption of the CRH Gene"

James Nelson, Ph.D., University of Texas Health Science Center at San Antonio

8:30 - 9:00 "Knockout and Transgenic Mouse Models to Define the Role of Oxidative Stress in Aging"

Holly Van Remmen, Ph.D., University of Texas Health Science Center at San Antonio

9:00 - 9:30 "Musculoskeletal Aging in Transgenic Mice Overexpressing hsp70"

Anne McArdle, Ph.D., Muscle Research Centre, Department of Medicine, University of Liverpool, UK

9:30 -10:00 "Loss of Leptin Sensitivity in Aging Hyperleptinemic Transgenic Mice"

Farid Chehab, Ph.D., Dept. of Laboratory Medicine, University of California San Francisco

10:00 -10:30 BREAK

Neural Stem Cells and the Aging Brain

Chair: Mark P. Mattson, Ph.D.

10:30 -11:00 "Molecular Mechanisms Regulating Stem Cell Differentiation"

Yi Sun, Ph.D., Dept. of Neurology, Children's Hospital and Harvard University, Boston, MA

11:00 -11:30 "Stem Cell Genetics and Aging"

Gary Van Zant, Ph.D., University of Kentucky, Lexington, KY

11:30 -12:00 "Neurogenesis in the Aging Brain"

Gerd Kempermann, M.D., Ph.D. University of Regensberg, Regensberg, Germany

12:00 -12:30 "Effects of Aging and Calorie Restriction on Neural Stem Cells"

Mark P. Mattson, Ph.D., National Institute on Aging, Baltimore, MD

12:30 - 2:00 LUNCH (on your own)

2:00 - 3:00 Annual Hayflick Award Lecture

Woodring Wright, M.D., Ph.D., University of Texas Southwestern Medical Center at Dallas, TX

3:00 - 3:15 BREAK

The Role of Exercise in Successful Aging

Chairs: John Holloszy, M.D. and Li Li Ji, Ph.D.

3:15 - 3:45 "Effect of Exercise on Longevity"

John Holloszy, M.D., Washington University, St Louis, MO

3:45 - 4:15 "Prevention and Treatment of Type II Diabetes with Exercise"

Loretta DiPietro, Ph.D., John B. Pierce Laboratories, Yale University School of Medicine, New Haven, CT

4:15 - 4:45 "Strength Training in the Prevention and Treatment of Frailty in the Elderly"

William Evans, Ph.D., Donald W. Reynolds Center on Aging, University of Arkansas Medical School, Little Rock, AR

4:45 - 5:15 "Exercise and Oxidative Stress During Aging"

Li Li Ji, Ph.D., University of Wisconsin, Madison, WI

5:30 - 6:00 AGE Business Meeting

6:00 - 8:30 Poster Session

TOP

Monday, June 4, 2001

Caloric Restriction Mimetics

Chair: George Roth, Ph.D.

8:00 - 8:30 "Beneficial Effects of Calorie Restriction Mimetic Dietary Supplements: A Cell Stress-Based Mechanism"

Mark P. Mattson, Ph.D., National Institute on Aging, Baltimore, MD

8:30 - 9:00 "CR and Non-Metabolizable Glucose Analogs Stimulate Growth Factor Production in the Brain"

Wenzhen Duan, Ph.D., National Institute on Aging, Baltimore, MD

9:00 - 9:30 "Caloric Restriction and CR Mimetics: Possible Relevance to Humans"

George Roth, Ph.D., Gerotech, Inc. and National Institute on Aging, Baltimore, MD

9:30 - 10:00 "DNA Microarrays as a Screening Tool for CR Mimetic Interventions"

Richard Weindruch, Ph.D., University of Wisconsin, Madison, WI

10:00 - 10:20 BREAK

Nutritional Interventions in Neurobiological Aging

Chairs: Barbara Shukitt-Hale, Ph.D. and James Joseph, Ph.D.

10:20 - 10:50 "The Effect of Dietary and Micro- and Macronutrients on Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease"

David G. Morgan, Ph.D., Univ. of South Florida, Tampa, FL

10:50 - 11:20 "Neuroprotective Strategies with Antioxidant Nutrients and Novel Neuroprotective Drugs in Progressive Neurodegenerative Diseases"

Moussa Youdim, Ph.D., Eve Topf and National Parkinson's Foundation Centers of Excellence for Neurodegenerative Diseases Research, Haifa, Israel

11:20 -11:50 "Natural Products as Blockers of Amyloid's Toxicity: Relevance to Alzheimer's Disease"

Remi Quirion, Ph.D., Dept. of Psychiatry, Douglas Hospital Research Center, Quebec, Canada

11:50 -12:20 "The Antioxidant and Anti-inflammatory Effects of Blueberries on Age-sensitive Tests of Behavior and Brain Function"

Barbara Shukitt-Hale, Ph.D., USDA, HNRC on Aging at Tufts University, Boston, MA

12:15 - 2:00 Annual Award Luncheon

2:00 - 3:00 Denham Harman Award Lecture

Arlan Richardson, Ph.D., University of Texas Health Science Center at San Antonio

TOP