Supplementation with a Concentrated Nutraceutical Food Reduces DNA Damage,
Oxidative Macromolecular Damage and Improves Lipid Profiles
Vincent C. Giampapa, MD, FACS & Gregory F. Sullivan II, Ph.D.
Assistant Clinical Professor, Plastic & Reconstructive Surgery
UMDNJ, Newark, NJ
The consumption of fruits and vegetables has been suggested to reduce the risk of many age-related diseases. Many studies indicate that certain components of food have beneficial effects on health; such a list of components would include vitamins, minerals, herbal extracts, trace minerals, digestive enzymes, electrolytes, antioxidants, cellular energy compounds, fatty acids, nucleic acids and amino acids. One possible mechanism by which food derived substances are suggested to exert their effects is by lowering the level of oxidative stress that macromolecules are subjected to in the body and the cell. In addition, evidence exist that diet pays an important role in the etiology of cardiovascular disease. In order to test the concept that three daily doses of a concentrated nutraceutical food (BioclockÕ) could shield macromolecules from oxidative damage and improve lipoprotein profiles, a supplement was designed to simulate the combinations of chemoprotective and health-promoting substances found in mixed diets.
Conclusions: As a result of supplementation for 1 month with the nutraceutical BioclockÕ the following changes were noted:
-Average plasma anti-oxidants showed a significant increase: ascorbate 41.0%, lycopene 16.3%, xeaxanthin 23.2%, tocopherols to plasma lipids ratio 27.9%.
-The rate of DNA damage as reflected by 8-hydroxyguanosine (urine), a mutated nucleotide that is excised by DNA repair enzymes, decreased by 51.1%. Markers .
-Markers of lipid peroxidation in the urine: total alkenals and 8-epi-Prostaglandin F2-alpha decreased by 43.3% and 56.8% respectively.
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