AGING FROM MOLECULES TO HUMANS:
Translational Research on Aging

American Aging Association
31st Annual Meeting

June 6 - 10, 2002

Bahia Resort Hotel
998 W. Mission Bay Drive, San Diego, California 92109

Thursday, June 6th: preconference workshop

Sarcopenia
Age-related Muscle Loss; Causes, Consequences and Preventions

Chair: Dr. Taylor Marcell

6:00 - 8:00: Registration

8:00 - 8:15: Welcome and Introduction - Dr. S. Mitchell Harman, Director, KLRI, Phoenix, AZ

8:15: Dessert and Coffee

Friday, June 7th: preconference workshop

7:30: Problems in Solving Sarcopenia, An Overview

Taylor Marcell, PhD, KLRI, Phoenix, AZ

8:00: Hormone Action in Skeletal Muscle, Basic Mechanisms and Effects of Aging

Stephen Welle, PhD, University of Rochester, Rochester, NY

9:00: Is Muscle Atrophy a Passive or Active Process?

H. Lee Sweeney, University of Pennsylvania, Philadelphia, PA

10:00: Break

10:30: Exercise, Aging, and Muscle Protein metabolisms

Kevin Yarasheski, PhD, Washington University, St. Louis, MO

11:30: Is There a Role for Oxidative Stress and Mitochondrial Induced Apoptosis in Sarcopenia?

Christiaan Leeuwenburgh, PhD, University of Florida, Gainsville, FL

12:30: Lunch (provided)

1:30: Sequelae and Importance of Age-Related Sarcopenia; Fails, Frailty, and Dependence

Ron Roubenoff, MD, MSH, Tufts University, Boston, MA

2:30: Hormone Replacement, Cure, Cause, or Both?

Shalender Bhasin, MD, Drew University School of Medicine, Los Angeles, CA

3:30: Break

4:00: Exercise and the Master Athlete - A Model of Success of Aging

Robert A. Wiswell, PhD, University of Southern California, Los Angeles, CA

5:00: Future of Sarcopenia Research and Treatment

John Holloszy, MD, Washington University, St. Louis, MO

6:00 - 6:30: Round Table Discussion and Q&A

Friday, June 7

5:00 - 6:00: Registration begins

6:00 - 8:00: Welcome reception

TOP

Saturday, June 8

7:00 - 8:00: Registration

8:00 - 8:15: Welcome and Introductory Remarks

Dr. Paula C. Bickford, University of South Florida, Tampa, FL

8:15 - 10:15: Mitochondria and Aging

Chair: Dr. Judd Aiken
University of Wisconsin, Madison, WI

8:15: "Role of Mitochondria in the aging process"

Dr. Rajindar Sohal, University of Southern California, Los Angeles, CA

8:45: "Cell-by-Cell analysis of mtDNA Mutations and the Mitochondrial Theory of Aging"

Dr. Konstantin Khrapko, Harvard Medical School, Boston, MA

9:15: "Mitochondrial DNA Deletion Mutations and Sarcopenia"

Dr. Judd Aiken, University of Wisconsin, Madison, WI

9:45: "Mitochondrial Oxidative Stress and Therapeutics"

Dr. Simon Melov, Buck Institute, Novato, CA

10:15 - 10:30: BREAK

10:30 - 12:30: Molecular outcomes of oxidative stress and aging: Molecules to Humans

Chair: Dr. Giulio Taglialatela
University of Texas Medical Branch at Galveston, TX

10:30: "Genotoxicity of electron transport inhibitors: Models of neurodegenerative diseases"

Dr. Ben Van Houten, NIEHS, Research Triangle Park, NC

11:00: "Free Radical-dependent bcl-2/NFkB Interactions in the Aged CNS"

Dr. Giulio Taglialatela, University of Texas Medical Branch at Galveston, TX

11:30: "Delaying Brain Mitochondrial Decay with Mitochondrial Antioxidant/metabolites, Acetyl-l-carnitine and R-a-lipoic Acid in Old Rats"

Dr Jiankang Liu, University of California, Berkeley, CA

12:00: "Differential Responses to Oxidative Stress in the Brain of Normal Aged Humans Versus Alzheimer's Disease"

Dr. Anne C. Andorn, University of Texas Medical Branch, Galveston, TX

12:30 - 1:30: LUNCH (on your own)

Chair: Dr. David Morgan
University of South Florida, Tampa, FL

1:30: "Inflammatory Mechanisms in Brain Aging: Possible Sites for Intervention"

Dr. David Morgan, University of South Florida, Tampa, FL

2:00: "The Influence of Age and Gender upon the effects of Chronic Neuroinflammation"

Dr. Gary Wenk, University of Arizona, Tucson, AZ

2:30: "Inflammatory Mechanisms in Alzheimer's disease: Microglial Signaling and Transcriptional Regulation"

Dr. Gary Landreth, Case Western Reserve University, Cleveland, OH

3:00: "Amyloid Precursor Protein and Activation of Microglia"

Dr. Steve Barger, University of Arkansas for Medical Sciences, Little Rock, AK

3:30 - 3:50: BREAK

3:50 - 4:50: Submitted paper session #1

Chair: Dr. Paula Bickford
University of South Florida, Tampa, FL

3:50: "Characterization of Long-lived Wild-derived House Mice (Mus musculus)"

Dr. Jean Harper, University of Michigan

4:05: "Physical Performance in Aged Rats Predicts Longevity: Implications for Assessing Preclinical Interventions"

Dr. Christy Carter, Wake Forest University School of Medicine

4:20: "Analysis of Changes in Mitochondrial Proteins with Age in Wildtype and MnSOD Knockout Mice"

Dr. Holly Van Remmen, University of Texas Health Science Center

4:35: "A Natural Model of Population Heterogeneity Fits Observed Mortality Distributions, Including Their Tail"

Dr. Aubrey de Grey, University of Cambridge

5:300 - 8:00: Annual AGE Board of Directors Meeting

TOP

Sunday, June 9

7:00 - 8:00: Registration

8:00 - 12:30: Cognition in Aging: Mechanisms and Interventions

Chairs: Drs. Paula C. Bickford and M. Claire Cartford
University of South Florida, Tampa, FL

Part 1: Associative Learning

8:00: "Exercise, Learning and the Aging Brain"

Dr. William Greenough, University of Illinois, Urbana, IL

8:30: "Mechanisms of Associative Learning in Young and Aging Hippocampus"

Dr. John F. Disterhoft, Northwestern University Medical School, Chicago, IL

9:00: "Teaching an Old Rat New Tricks: Cerebellar Motor Learning"

Dr. Paula C. Bickford, University of South Florida, Tampa, FL

9:30: "Parallels in Age-related Changes in Learning and the Cerebellum"

Dr. Diana Woodruff-Pak, Temple University, Philadelphia, PA

10:00 - 10:30: BREAK

Part 2: Cognition in Aging

10:30: "Cognitive Deficits in Aging: Changes in Circuits Without Loss of Neurons"

Dr. Michela Gallagher, Johns Hopkins University, Baltimore, MD

11:00: "Preservation of Cognitive Function in Aged Canines: Collaborative Effects of an Antioxidant Enriched Diet and Cognitive Experience"

Dr. Bill Milgram, University of Toronto. Toronto, Ontario

11:30: "The Aging Hippocampus, Molecules, Maps, and Memory in Rats and Non-Human Primates"

Dr. Carol Barnes, University of Arizona, Tucson, AZ

12:00: "Parallels in cognitive function of aged monkeys and humans"

Dr. Mary Lou Voytko, Wake Forest University School of Medicine, Winston-Salem, NC

12:30 - 2:00: LUNCH (on your own)

2:00 - 4:00: The Use Of Antioxidants To Maximize Brain Function

Chair: Dr. Barbara Shukitt-Hale
Tufts University, Boston, MA

2:00: "Brain Gene Expression is Modified by Gingko Biloba Extract EGb 761 and in A-Tocopherol Deficient Mice"

Dr. Lester Packer, University of California, Berkeley, CA

2:30: "Impairment in Synaptic Plasticity in the Rat Hippocampus Can be Reversed by Dietary Manipulation: Evidence Favouring a Significant Role for Interleukin-1beta"

Dr. Marina Lynch, Trinity College, Dublin, Ireland

3:00: "Age-related changes in cognition and the brain of the Rhesus monkey: evidence for inflammatory processes in white matter"

Dr. Douglas Rosene, Boston University School of Medicine, Boston, MA

3:30 - 3:50: BREAK

3:50: "Signaling Oxidative Stress in Alzheimer Disease"

Dr. Mark Smith, Case Western Reserve University, Cleveland, OH

4:20 - 4:50: Submitted paper session #2

Chair: Dr. Mark Lane, GRC, NIA, Baltimore, MD

4:20: "Mitochondrial Role in Age-Related Responses of Neurons to A-Beta and Glutamate"

Dr. Gregory Brewer, Southern Illinois University School of Medicine

4:35: "Oxidative Damage and the Mitochondrial Membrane in Age-related Cataract"

Dr. Norman Wolf, University of Seattle

5:00 - 5:45: AGE Business Meeting

6:00 - 8:00: Poster Presentation and Cocktail Reception
Competition for Nicolai Prize and Glenn Award

TOP

Monday, June 10

8:00 - 10:00: Estrogen Neuroprotection: From Molecules to Humans

Chair: James W. Simpkins
University of North Texas Health Science Center, Ft. Worth, TX

8:00: "Structure-Neuroprotective Activity Relationships Among Estrogens and Related Molecules"

Dr. James W. Simpkins, University of North Texas Health Science Center, Ft. Worth, TX

8:30: "Development of Model Systems to Assess the Role of Estrogens in Neuroprotection"

Dr. Darlene Coleman Deecher, Women's Health Research Institute, Wyeth Research

9:00: "Unifying Mechanism of Estrogen-Induced Neuroprotection"

Dr. Roberta Brinton, University of Southern California, Los Angeles, CA

9:30: "Cognitive Effects of Estrogens in Normal Women and Alzheimer's Disease Subjects"

Dr. Victor Henderson, University of Arkansas for the Medical Sciences, Little Rock, AK

10:00 - 10:15: BREAK

10:15: Annual Hayflick Award Lecture

"Molecular genetic studies of replicative senescence: a role for chromatin re-modelling"
Dr. Olivia Pereira-Smith, University of Texas Health Science Center

11:15 - 12:00: Submitted paper session #3

Chair: Dr. Mark Lane, GRC, NIA, Baltimore, MD

11:15: "Regional Differences in Age-Related Changes in NMDA Receptor Expression within the prefrontal cortex and hippocampus"

Dr. Kathy Magnusson, Colorado State University

11:30: "Effect of Age and Estradiol on Fine Motor Skills in Female Rhesus Monkeys"

Dr. Agnes Lacreuse, Emory University

11:45: "Estrogen Effects on Septal Cholinergic Neurons in Culture"

Dr. James Stoll, Texas Tech University Health Science Center

12:00 - 2:00: Annual Award Luncheon

2:00: Denham Harman Award Lecture

"Caloric restriction: new tires on an old model"
Dr. Donald Ingram, National Institute of Health

3:00: C O N F E R E N C E A D J O U R N S

Thank you for your attendance and participation!