Friday, June 4, 2004

7:00 am 

Registration

Pre-conference—EXERCISE TO PROMOTE HEALTHY AGING

Sponsored by Kronos Longevity Research Institute (KLRI) and Biochemistry of Aging Laboratory, University of Florida

7:30 pm–8:30 pm

PUBLIC LECTURE—Christiaan Leeuwenburgh, PhD

Saturday, June 5, 2004

7:00 am

AGE Meeting Registration

8:00 am

AGE Meeting Sessions Begin

8:00 am–8:10 am

Opening Remarks—Norman S.Wolf, DVM, PhD, President, American Aging Association

8:10 am–10:10 am

Session 1:  Non-murine Vertebrate Models of Aging: Mechanistic Similarities and Differences

Chair: George S. Roth, PhD

8:10 am

Rochelle Buffenstein, PhD—Testing Mechanisms of Aging in the Longest-living Rodent, the Naked Mole-Rat

8:40 am

Donna Holmes, PhD—Why Do Birds Live so Long?

9:10 am

David Reznick, PhD—Comparative Studies of Senescence in Natural Populations of Guppies

9:40 am

George S. Roth, PhD—Non-Human Primate Models of Caloric Restriction and Aging

10:00 am–10:30 am

B R E A K

10:30 am–12:30 pm

Session 2:  Invertebrates: Hormones, Receptors and Genes, Effects on Lifespan

Chair: Thomas E. Johnson, PhD

10:30 am

Valter Longo, PhD—Pathways that Regulate the Yeast Replicative and Chronological Life Spans and Similarities with Higher Eukaryotes

11:00 am

Gordon Lithgow, PhD, Buck Institute on Aging—Molecular Chaperones, Stress Response and Lifespan in C.elegans

11:30 am

Marc Tatar, PhD—Endocrine Control of Aging in Drosophila

12:00 pm

Thomas Johnson, PhD—Metabolism and Stress Resistance in Age Mutants of C. elegans

12:30 pm–1:30 pm

L U N C H   (on your own)

1:30 pm–3:30 pm

Session 3:  Mutational Versus “Normal” Models for Aging: Comparative Feature

Chair:  Andrzej Bartke, PhD

1:30 pm

Richard Maser, PhD— Aging and Degenerative Disease in the Telomerase Mutant Mouse

2:00 pm

Andrzej Bartke, PhD—Interaction of Caloric Restriction with Murine Longevity Genes

2:30 pm

Richard Miller, MD—Genetics and Gene Expression Studies of Aging in Mice

3:00 pm

David Harrison, PhD—Genetic Regulation of Mammalian Aging

3:30 pm–4:00 pm

B R E A K

4:00 pm–5:15 pm

Session 4:  Short Paper Session

4:00 pm 

Christy Carter, PhD—ACE Inhibition Intervention: Implications for Improving Age-Related Declines in Physical Performance and Longevity

4:15 pm

Leonie Heilbronn, PhD—The Effects of 6-Months of Calorie Restriction on Biomarkers of Aging in Non-Obese Humans

4:30 pm

Kenichi Kitani, MD, Phd—The Presence of an Optimal Dose Range May Explain Discrepancies in the Effects of (-)Deprenyl (D) on Survivals of Animals in Past Reports

4:45 pm

Janko Nikolich-Zugich, MD, PhD—Phenotypic, Functional and Genetic Profiles of the Aging T-Lymphocytes in Primates and their Alteration by Caloric Restriction

5:00 pm

Liou Sun, MD— Hippocampal GH and IGF-1 Expression in GH-Deficient Mice

5:15 pm

AGE Meeting Sessions Adjourn for the Day

5:30 pm–7:45 pm

The American Aging Association’s AnnualBoard of Directors’ Dinner Meeting

8:00 pm

NIA Aging Intervention Testing Program--Call for Proposals and Discussion

Sunday, June 6, 2004

7:00 am

AGE Meeting Registration

8:00 am–10:00 am

Session 5:  The Molecular Bases of Cell Senescence

Chair:  Judy Campisi, PhD, Lawrence Berkeley National Laboratory

8:00 am

Jerry Shay, PhD—Do Short Telomeres Signal Replicative Senescence? 

8:30 am

Richard Faragher, PhD—Why Werner's Syndrome Patients Look the Way They Do

9:00 am

Olivia Pereira-Smith, PhD—Studies of the Role of the MORF/MRG Gene Family in Cell Senescence

9:30 am

Judy Campisi, PhD—Role of Cellular Senescence in Cancer and Aging 

10:00 am–10:20 am

B R E A K

10:20 am–11:35 am

Session 6:  Short Paper Session

10:20 am 

Gregory Brewer, PhD—Aging Neuron Mitochondrial Function and Rejuvenation with Estrogen or Mitosis

10:35 am

Sandy Chang, PhD, MD—Essential Role of Limiting Telomeres in the Pathogenesis of Werner Syndrome

10:50 am 

Warren Ladiges, PhD—Age-associated Cellular Stress in HSP-40 Molecular Chaperone Mutant Mice

11:05 am

Aasef G. Shaikh, MD, PhD—cAMP Forms a Neurochemical Correlate of Tinnitus

11:20 am

Donna M. Wilcock, PhD—Passive Amyloid Immunotherapy Clears Amyloid and Transiently Activates Microglia in a Transgenic Mouse Model of Amyloid Deposition

11:35 am–1:00 pm

L U N C H  (on your own)

1:00 pm–3:00 pm

Session 7:  Control of Cell Cycle Activity and Cancer in Aging and Senescence

Chair: George Martin, MD

1:00 pm

Tomas Prolla, PhD—The Gene Expression Profile of Aging in Skeletal Muscle: Evidence for Oxidative Stress and p53-mediated Transcriptional Responses and Induction of Cell-cycle Related Genes

1:30 pm

Thomas von Zglinicki, PhD—Cell Senescence in Vitro and in Vivo

2:00 pm

Chu-Xia Deng, PhD—Roles of BRCA1 in Cell Cycle Checkpoints and Aging

2:30 pm

Irving Weissman, MD—The Relationship of Stem Cells to Animal Aging            

3:00 pm–3:20 pm

BREAK

3:20 pm–5:20 pm

Session 8:  The Role of Mitochondria and Oxidative Damage in Age-related Changes and Disease

Co-Chairs:  Norman S. Wolf, DVM, PhD and Holly Van Remmen, PhD

3:20 pm

David Nicholls, PhD—Mitochondrial ATP Synthesis, Calcium Regulation and Reactive Oxygen Control – Keeping Three Balls in the Air

3:50 pm

Norman S. Wolf, DVM, PhD—Measurements of Mitochondrial Membrane Potential, Oxygen Utilization, and Peroxide Production in the Intact Aging Lens

4:20 pm

Holly Van Remmen, PhD—Impact of Deficiencies in Mitochondrial Antioxidant Defense on Mitochondrial Function During Aging

4:50 pm

Janine Santos, PhD—Oxidative Stress and Mitochondrial DNA Damage: Sorting out Life and Death Decisions

5:20 pm

AGE Meeting Sessions Adjourn for the Day

5:20 pm–6:00 pm

Business Meeting of the American Aging Association  - Open to All Members

7:15 pm–8:00 pm

Huber Warner, PhD, National Institutes on Aging, NIH

CURRENT GOALS AND PROJECTIONS OF THE NIA DIVISION OF BIOLOGY OF AGING. 

8:00 pm–10:00 pm

Poster Presentation and Cocktail Reception

Competition for Nicolai Prize and Glenn Award

Monday, June 7, 2004

7:00 am

AGE Meeting Registration

8:00 am–10:00 am

Session 9:  Aging and DNA Damage Responses

Chair: Jan Vijg, PhD

8:00 am

Vilhelm Bohr, MD, PhD—Premature Aging Proteins: Links Between DNA Repair and Aging

8:30 am

Jan Vijg, PhD—Genomic Instability and Aging

9:00 am

Ahmad R. Heydari, PhD—Age-related Decline in Base Excision Repair as Mechanism for Decreased Genomic Stability with Age

9:30 am

Ian Hickson, PhD—Premature Aging and Cancer Predisposition in RecQ Helicase - Deficient Disorders

10:00 am–10:30 am

B R E A K

10:30 am–12:30 pm

Session 10: The Nervous System: Age-related Changes and Protection from Deterioration

Chair: Paula Bickford, PhD

10:30 am

Robert A.Floyd, PhD—What Have We Learned About Aging from Studying the Nitrones?

11:00 am

Paula Bickford, PhD—Oxidative Stress and Inflammation in the Aged Brain

11:30 am

Ashley Bush, MD, PhD—The Metallobiology of Alzheimer’s Disease and Other Neurodegenerative Diseases

12:00 pm

Simon Melov, PhD—Gene Expression Profiling of Neuronal Oxidative Stress and Aging    

12:30 pm

Annual Awards Luncheon

                        Distinguished Achievement Award—George Martin, MD

                        Harman Research Award—James Joseph, PhD

Nicolai and Glenn Awards

2:15 pm

Harman Award Lecture—James Joseph, PhD, USDA, HNRCA at Tufts University

“MULTIPLE PROPERTIES OF FRUITS AND VEGETABLES IN THE

 BENEFICIAL EFFECTS ON BRAIN AGING AND BEHAVIOR”

3:15 pm

AGE MEETING ADJOURNS