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FRIDAY, JUNE 1, 2007 |
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Pre-meeting workshop:
“Therapeutic Intervention in the
Aging Process”
Chair:
Randy Strong, PhD, UTHSCSA, TX |
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7:00 AM |
Pre-meeting workshop registration at the Henry B.
Gonzalez Convention Center, Mission Room 103 B |
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8:00 |
Pre-conference Welcome and Opening Remarks |
Chair: Randy
Strong, PhD, UTHSCSA, TX |
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8:05-9:35 |
Session 1 –
Identification of Therapeutic Targets |
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8:05 |
Use of Gene Arrays to Identify Therapeutic Targets |
Richard Weindruch, PhD,
University of Wisconsin, WI |
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8:35 |
Identification of Longevity Genes: Yeast to Mammals |
Brian Kennedy, PhD,
University of Washington, MO |
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9:05 |
A Critical Evaluation of Anti-Oxidant Defense Systems as
Targets for Anti-Aging Intervention |
Arlan Richardson, PhD,
UTHSCSA, TX |
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9:35-10:00 |
Break |
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10:00-11:30 |
Session 2
– Screening for Potential Therapeutic Compounds |
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10:00 |
Stress Response Mimetics
and Aging |
Gordon Lithgow, PhD, Buck
Institute, CA |
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10:30 |
Anti-convulsants Medicines
Delay Nematode Aging |
Kerry Kornfeld, PhD,
Washington University, MO |
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11:00 |
A Large-Scale Screen System for Prolongevity
Interventions Using the Mexican Fruit Fly Anastrepha
ludens |
Sige Zou, PhD, NIA, MD |
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11:30
AM-1:00 PM |
Lunch (on your own) |
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1:00-2:30 |
Session 3
– Testing Interventions in Rodent Models |
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1:00 |
Development of the NIA Interventions Testing Program |
Nancy Nadon, PhD, NIA, MD |
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1:15 |
Long-Term Administration of Compounds to Rodents:
Technical Challenges and Solutions |
Randy Strong, PhD, UTHSCSA,
TX |
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1:30 |
NIA
Intervention Testing Program: Initial Results |
Richard Miller, MD, PhD,
University of Michigan, MI |
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2:00 |
Lifespan Extension by
Resveratrol |
Rafael de Cabo, PhD, National Institute on Aging, MD |
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2:30-3:00 |
Break |
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3:00-4:30 |
Session 4
– Clinical Research: Challenges and Opportunities |
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3:00 |
Geneticor Pharmacologic
Blockade of Ghrelin Receptor Signaling Improves Glucose
Homeostasis |
Peter DiStefano, PhD,
Elixir Pharmaceuticals, MA |
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3:30 |
What
Have Nitrones Taught Us About Aging and Age Related
Diseases? |
Robert Floyd, PhD, FAAA, Oklahoma
Medical Research Foundation, OK |
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4:00 |
The CALERIE study:
Calorie Restriction in Humans - Opportunities for Research
|
Steven Smith, MD,
Pennington Center, LA |
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4:30 |
Pre-conference adjourns |
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6:00-7:30
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AGE
Registration at Marriott Plaza San Antonio |
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6:00-7:30 |
Welcome Reception
at Marriott Plaza San Antonio |
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SATURDAY, JUNE 2, 2007 |
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7:00 AM |
AGE Conference Registration
and Continental Breakfast at Marriott Plaza San Antonio |
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8:00-8:10 |
Introduction and Opening Remarks – Holly Van Remmen,
PhD, FAAA, AGE President and Meeting Chair |
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8:10-9:40 |
Session
1 –
Using
Invertebrate Models as a Discovery Tool for Genes and
Processes that Determine Life Span and Aging Rates
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Session
Chair: Pamela Larsen, PhD, UTHSCSA |
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8:10-8:40 |
Systematic Analysis of
Genetic Determinants of Longevity in
C. elegans |
Siu
Sylvia Lee, PhD,
Cornell University Ithaca, NY |
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8:40-9:10 |
The Genetics
of Aging and Age Related Diseases |
Andrew Dillin, PhD,
Salk Institute for
Biological Studies,
CA |
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9:10-9:40 |
Probing
the Role of Reactive Oxygen in DR in Drosophila:
Differential
Responses of Mutants Deficient in Sod1, Sod2 or Cat |
John
P. Phillips, PhD, University of Guelph, Canada |
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9:40 -10:15 |
Break |
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10:15 AM-12:15
PM |
Session
2 – Probing the Role of IGF-1 in Aging |
Session
Chairs: Martin Adamo, PhD, UTHSCSA, TX
and
Andrzej Bartke, PhD, FAAA, Southern Illinois University, IL |
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10:15-10:45 |
Aging
in the Growth Hormone, IGF-1: Novel Insights from an
Investigation of the Hippocampal Proteome |
William Sonntag, PhD, Wake Forest University, NC |
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10:45-11:15 |
Suppression of Aging in Mice by the Hormone Klotho |
Makoto Kuroo,
PhD, University of Texas Southwestern Medical Center at
Dallas, TX |
|
11:15-11:45 |
Aging
in IGF-1 Hypomorphic Mice |
Christian
Sell,
PhD,
Drexel University, PA |
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11:45
AM-12:15 PM |
Studying
the Role of IGF1 in Aging Using Mice Deficient in Liver
IGF1 (LID
Mice) |
Martin Adamo,
PhD,
UTHSCSA, TX |
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12:15-1:30
PM |
Lunch (on your own) |
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1:30-2:45 |
Special
Event:
Debate -
"Is aging programmed?" |
Moderated by Steve Austad, UTHSCSA, TX
Panelists: Daniel
Promislow, PhD, University of Georgia, GA
and Valter Longo, PhD, USC, CA |
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2:45 - 3:15 |
Break |
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3:15-5:15 |
Dual Sessions: |
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Submitted Paper Session: short papers chosen from
submitted abstracts |
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How Persistent Viruses Drive Immune Senescence and What
Can We Do About It? |
Janko Nikolich-Zugich, MD, PhD, Oregon Health and
Science University |
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Telomerase Activity and Tumor Suppression: From Mice to
Beavers |
Vera Gorbunova, PhD, University of Rochester |
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Age-Related Changes in Insulin-Like Growth Factor-I in
Ischemia/ Reperfusion Injured Skeletal Muscle |
David Hammers, The University of Texas at Austin |
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Comparative Biology of DNA Repair |
Andrej Podlutsky, PhD, University of Texas Health
Science Center at San Antonio |
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Human Umbilical Cord Blood Cells Increase in Vivo
Proliferation of Endogenous Hippocampal Progenitor Cells
of Aged Rats |
Adam Bachstetter, University of South Florida |
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Mitochondrial Dysfunction Leads to Age Dependent Loss of
Muscle Mass Via Apoptotic Myonuclear Deletion and
Proteolysis in Mice Lacking SOD1 |
Young Jang, University of Texas Health Science Center at
San Antonio |
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A Multi-Parameter Biomarker Set for Oxidative Stress
Assessment in Human Samples |
Chris Heward, PhD, Kronos Science Laboratory |
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Trans-Atlantic Awareness and Collaboration Symposium on
Aging Research |
Chairs: Anne McArdle, PhD, University of Liverpool and
Norman Wolf, DVM, PhD, FAAA, University of Washington |
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What Has Cell Senescence Got to do with Ageing? |
Richard Faragher, PhD, University of Brighton, UK |
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Stress and Immunity in Old Age |
Janet Lord, PhD, University of Birmingham, UK |
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It's about Time: Ageing and the Circadian Clock. |
Stephany Biello, PhD, University of Glasgow, UK |
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Can Snails Help Slow the Pace of Ageing? |
Mark Yeoman, PhD, University of Brighton, UK |
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Molecular Structure and Function in Ageing Elastic
Fibres |
Mike Sherratt, PhD, University of Manchester, UK |
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Oxygen Free Radicals in Senescence, Are They Signal
Transducers? |
Joćo Passos, PhD, Newcastle University, UK |
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Trans-Atlantic Studies of ROS and Skeletal Muscle Ageing |
Malcolm Jackson, PhD, Liverpool University, UK |
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6:30-8:30 |
AGE
Board of Directors Meeting |
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6:30 |
Student
Data Blitz, Panel Discussion and Social |
Chair:
Rafael de Cabo, PhD, National Institute on Aging, MD |
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SUNDAY, JUNE 3, 2007 |
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7:00 AM |
AGE Conference Registration
and Continental Breakfast at Marriott Plaza San Antonio |
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8:15
AM – 9:45 PM |
Session
3 – Nutrient Sensing |
Session
Chair:
Walter Ward, PhD,
and
David Sharp, PhD, UTHSCSA
|
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8:15-8:45 |
Branch Chain Amino Acid
Signaling to the mTOR Pathway |
Jim
Jefferson, PhD, Pennsylvania State University, PA |
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8:45-9:15 |
Nutrient Signaling to the
mTOR
Pathway |
George
Thomas PhD, University of Cincinnati, OH |
|
9:15-9:45 |
Nutrient Control of Glucose
Homeostasis through the PGC-1 Pathway |
Pere
Puigserver, PhD, University of Washington, WA |
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9:45-10:15 |
Break |
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10:15AM –
12:15 PM |
Nathan Shock Center Symposium
Submitted
Papers from Abstracts |
Chair:
Arlan Richardson, PhD, University of Texas Health
Science Center at San Antonio |
|
CALCIUM OVERLOAD, ATP
INSUFFICIENCY AND OXIDATIVE STRESS: THREE ASPECTS OF
MITOCHONDRIAL DYSFUNCTION |
David
G. Nicholls, PhD, Buck Institute for Age Research
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ENHANCED ASTROCYTE
MITOCHONDRIAL METABOLISM DURING
AGING |
James
D. Lechleiter, PhD, University of Texas Health Science
Center at San Antonio
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CELL STRESS AND AGING:
STUDIES OF MUTANT MICE AND LONG-
LIVED RODENTS |
Richard
Miller, MD, PhD, University of Michigan
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MOUSE MODELS FOR
SPONTANEOUS CHANGES WITH AGE AND
HAPLOTYPE ANALYSES |
Rong
Yuan, MD, PhD, The Jackson Laboratory |
SUCCESSFUL GENERATION OF
TRANSGENIC MOUSE MODELS FOR
AGING RESEARCH |
Warren
C. Ladiges, PhD, University of Washington |
|
SUBMITTED
PAPERS FROM ABSTRACTS |
Chair:
Julie Mattison, PhD, National Institute on Aging |
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EFFECTS OF DIET RESTRICTION
AND THE LITTLE MUTATION ON HEMATOPOIETIC STEM CELL AGING
AND THE RISK OF CANCER |
David E. Harrison, PhD, The
Jackson Laboratory
|
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CALORIE RESTRICTION AND TOR
SIGNALING CONVERGE ON SIRTUIN-MEDIATED LIFESPAN
EXTENSION IN SACCHAROMYCES CEREVISIAE |
Dudley W. Lamming, Harvard
Medical School
|
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CALORIE RESTRICTION AND
INSULIN RECEPTOR ACTIVATION IN LIVER AND MUSCLE FROM
NORMAL AND GROWTH HORMONE RECEPTOR KNOCKOUT MICE |
Michael Bonkowski, Southern
Illinois University
|
|
Cu/ZnSOD TRANSGENIC RATS: A
NEW ANIMAL MODEL FOR OXIDATIVE STRESS THEORY OF AGING? |
Yuji Ikeno, PhD, University
of Texas Health Science Center at San Antonio |
TEN-FOLD EXTENSION OF C.
ELEGANS LONGEVITY BY MUTATIONS THAT ALSO CONFER
PROTECTION AGAINST
OXIDATIVE AND ELECTROPHILIC STRESSES, BUT NOT
HYPERTHERMIC STRESS |
Robert Shmookler Reis, PhD,
University of Arkansas for Medical Sciences
|
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12:15-1:30 |
Lunch (on your own) |
|
1:30-3:00 |
Session
4 – Comparative Biology of Aging |
Session
Chair: Rochelle Buffenstein, PhD, City College of New
York, NY |
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1:30-2:00 |
Membrane Lipids and Aging |
A.J. (Tony)
Hulbert, PhD, Metabolic Research Centre,
University of Wollongong, Australia |
|
2:00-2:30 |
Aging in Wild Mice/Caloric
Restriction with and without Parasite Infections |
Debbie
Kristan, PhD, California State University San Marcos, CA |
|
2:30-3:00 |
Holes in the Oxidative
Stress Theory of Aging: ROS Resistance and Rodents with
Disparate Longevity |
Rochelle
Buffenstein, PhD, City College of CUNY, NY |
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3:00-3:30 |
Break |
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3:30-5:00 |
Submitted Paper Session: short papers chosen from
submitted abstracts |
Chair:
Mark Smith, PhD, Case Western Reserve University |
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REDUCTION OF NEOPLASIA IN
OLD MICE OVEREXPRESSING MITOCHONDRIAL-TARGETED CATALASE |
Piper Treuting, PhD,
University of Washington |
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NEURONAL INSULIN/IGF-I
SIGNALING AND THE REGULATION OF MAMMALIAN LIFESPAN |
Fresnida J. Ramos,
University of Texas Health Science Center at San Antonio |
|
FOXO1 IS NOT INVOLVED IN
THE CALORIE RESTRICTION-SPECIFIC RESPONSE TO OXIDATIVE
STRESS IN MICE LIVER |
Isao Shimokawa, MD, PhD,
Nagasaki University Graduate School of Biomedical
Sciences |
|
ANTI-AGING EFFECTS OF PGC-1
ALPHA OVEREXPRESSION |
Huiyun Liang, PhD,
University of Texas Health Science Center at San Antonio |
|
Submitted Paper Session: short papers chosen from
submitted abstracts |
Chair:
James Nelson, University of Texas Health Science Center
at San Antonio |
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THE ADULT CARDIOPROTECTIVE
STRESS RESPONSE CAN BE CONVERTED TO THE AGED PHENOTYPE
BY KATP CHANNEL |
Sandeep Sagar, MD, PhD,
Mayo Clinic
|
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STRAIN VARIATION IN THE
RESPONSE OF FAT MASS TO CALORIC RESTRICTION |
Chen-Yu Liao, University of
Texas Health Science Center at San Antonio |
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IDENTIFICATION OF
DOWNSTREAM TARGET GENES OF SKN-1-DEPENDENT OXIDATIVE
STRESS RESPONSE |
Sang-Kyu Park, PhD,
University of Colorado at Boulder |
|
AGE-RELATED TOXICITY OF Β-AMYLOID
ASSOCIATED WITH INCREASED ROS, P-ERK AND P-CREB IN
PRIMARY HIPPOCAMPAL NEURONS: REVERSAL BY BLUEBERRY
EXTRACT |
Gregory Brewer, PhD,
Southern Illinois University |
|
5:15-5:45 |
AGE Business Meeting – Open to all Members |
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6:30-8:30 |
Poster
Session and Cocktail Reception
Competition for the Paul F. Glenn Award and the Walter
R. Nicolai Prize |
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MONDAY, JUNE 4, 2007 |
|
7:00 AM |
AGE Conference Registration
and Continental Breakfast at Marriott Plaza San Antonio |
|
8:30-10:30
AM |
Session
5 – Genetics of Aging: How Aging and Longevity are
Controlled by Genes |
Session
Chair: Yousin Suh, PhD, UTHSCSA, TX |
|
8:30-9:00 |
Strategies for Searching
for Aging and Longevity Genes in Humans |
Charles
Cantor, PhD, Sequenom, San Diego, CA |
|
9:00-9:30 |
Functional Genomics
Approaches for Identification of Human Longevity Genes |
Nir
Barzilai, MD, Albert Einstein College of Medicine, NY |
|
9:30-10:00 |
Genetics of Inflammation in
Age-Related Diseases and Longevity |
Calogero
Caruso, MD, University of Palermo, Italy |
|
10:00-10:30 |
Mapping
Genes Specifying the
Anti-Aging Actions of Calorie Restriction Using QTL
Approaches |
Brad
Rikke, PhD, University of Colorado, CO |
|
10:30-10:50 |
Break |
|
10:50 AM –
12:20 PM |
Session
6 – Stem Cells and Aging |
Session
Chair: Peter Hornsby, PhD, UTHSCSA |
|
10:50-11:20 |
Muscle Derived Stem Cells |
Johnny Huard,
PhD,
Children's Hospital of Pittsburgh and University of
Pittsburgh, PA |
|
11:20-11:50 |
Muscle Neural Stem Cells |
Sean
J. Morrison,
PhD,
University of Michigan, MI |
|
11:50 AM
-12:20 PM |
Applications of Human Embryonic Stem Cells for Cardiac
Repair |
Charles E. Murry, MD, PhD, Institute for Stem Cell and
Regenerative Medicine, University of Washington, WA |
|
12:30-2:00
PM |
American Aging Association Awards Luncheon (at
Hilton Hotel - two blocks away from the conference
venue)
All meeting registrants invited |
|
|
Poster
Awards: Paul F. Glenn Award and Walter R. Nicolai Award |
|
|
Distinguished Achievement Award
Edward J.
Masoro, PhD,
University of Texas Health Science Center at San Antonio |
|
2:15 |
Denham
Harman Award Lecture for 2007 (held at Marriott Plaza)
SEEING CLEARLY BY
MAINTAINING PROTEOLYTIC EDITING AND EATING RIGHT
Allen Taylor, PhD - Jean Mayer USDA Human Nutrition
Research Center on Aging at Tufts University
|
|
3:15 |
Meeting closes |
