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2006
Annual Meeting |
Announcements
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- Our Brochure
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Call
for Abstracts
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Sponsorship/Exhibit
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Our
Supporters
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IN THE SPOTLIGHT:
Trans-Atlantic Awareness
& Collaboration Symposium on Aging
Research
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Welcome to our AGE New Members!
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Father of the Free Radical Theory of
Aging Still Going Strong at 90
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Grant Announcements
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35th AGE ANNUAL MEETING
- June 2-5, 2006 |
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MEETING BROCHURE
Our meeting
brochure (including our program,
details on registration and accommodation,
speakers, etc.) is available as a PDF
download (see red box to the right).
CALL FOR
ABSTRACTS
 DEADLINES:
March 15, 2006 - Abstract Submission
Apri 1, 2006 - Early Bird
Registration |
Participants who wish to make an oral or a
poster presentation at this meeting must
submit an abstract which will be reviewed by
the Scientific Committee. Results of this
review will be communicated via email, to
each applicant. Please note that only
the abstract of the registered presenters
will be included in the program and the
Conference Handbook.
Submission deadline is March 15, 2006.
To submit your abstract today,
click here.
EXHIBIT/SPONSORSHIP
The 35th
American Aging Association Annual
Meeting offers great
opportunities to expand your
company's visibility among the
registrants by becoming an exhibitor
and/or conference sponsor.
These will include multiple
opportunities to:
- introduce and discuss your
products and services with
leading basic science
researchers and clinicians of
the aging field
- reach decision makers
within a group-setting
-
open door to
new leads and
long-term business relationships
- increase exposure and
strengthen brand recognition
in the aging research field.
Attendees include many decision
makers, such as academic department chairs,
heads of laboratories, government
officials, attending
clinicians, private practitioners,
post-docs, MD and PhD students and
technicians. You will be hard pressed to
find a more appropriate audience for
your latest products and services.
Consider becoming a sponsor today and
take advantage of extensive
advertising opportunities via our
newsletter and website!
OUR SUPPORTERS
The 35th American
Aging Association Annual Meeting Organizers
are most grateful for the support of the
following organizations:
PLATINUM
SPONSORS
GOLD SPONSORS
SILVER SPONSORS
BRONZE SPONSORS
SCHOLARSHIP SPONSORS:
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ANNUAL MEETING SESSION SPOTLIGHT |
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Following the first three presentations (see
our
September issue on Sarcopenia: Cause, Effect
and Treatment,
the
October
issue on Immunity and Infection,
the
November issue on the Pre-Meeting
Symposium on Caloric Restriction,
the
December issue on
the Current
Advances in Understanding the Basic
Biology of Aging
and the
January issue on the
Intervention in Aging and Age-Related
Skin Diseases), we are continuing our
series with a brief presentation of the session on
Trans-Atlantic Awareness
& Collaboration Symposium on Aging
Research
chaired by Dr.
Richard Faragher (scheduled for
Sunday, the
4th of
June, 2006). As
always,
we encourage your comments and questions.
Trans-Atlantic Awareness
& Collaboration Symposium on Aging
Research
CHAIR:
Richard Faragher, PhD
 Richard
Faragher, PhD, University of
Brighton -
Dr. Faragher read
Biochemistry at Imperial
College, London and
following his degree
undertook doctoral studies
at the University of
Sussex. He joined the
University of Brighton in
1994. Dr. Faragher's
primary research interest is
the relationship between
replicative senescence and
organismal aging with
particular emphasis on the
cell biology of Werner's
syndrome. This year he
became the first ever
scientist to receive a
Help the Aged award for
his championship of older
people and the use of
research for their benefit.
In 2002, he received the
Royal Pharmaceutical Society
medal for Outstanding
Scientific Achievement for
his work on Werner's
syndrome. He is a member of
the BBSRC-Experimental
Research on Ageing (ERA)
special initiative
committee, the Research
Advisory Council of Research
into Ageing and was
Treasurer of the British
Society for Research on
Ageing (1999-2003). Dr
Faragher is currently
co-director of the SPARC
programme, a UK government
sponsored initiative
designed to build national
capacity to conduct
inter-disciplinary ageing
research. Read more at
www.sparc.ac.uk.
Co-Chair: Norman Wolf, DVM,
PhD
 Norman
Wolf, DVM, PhD, University of Washington
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Dr. Norm
Wolf's background first in veterinary
laboratory animal medicine and
additionally in basic cellular
physiology has provided him with and
understanding of both the physiologies
and the pathologies of the several
laboratory animal species used in his
research. His research deals with the
age-related loss of cell and tissue
function with aging, and uses both in
vivo and in vitro techniques to reach
that goal. His recent studies are
directed toward the physiopathology of
the lens and the conditions that lead
to, and the specific mechanisms that
produce age-related cataract (ARC). At
present his laboratory has demonstrated
the abnormal migration of lens
epithelial cells and the incomplete
differentiation of lens fiber cells in
the aged mouse and rat, with ongoing
studies to determine whether these
events apply also to non-human and human
primates. The incomplete resolving of
the organelles (nucleus, mitochondria
and membranes) by the internalizing and
differentiating lens fiber cells result
in an accumulation of nuclear and
mitochondrial debris and reactive oxygen
species at the site of cortical/subcapsular
cataract in old animals. The
relationship of available antioxidant
enzymes and DNA repair protein
functions, as well as the lysosomal and
proteosome clearance of this residual
debris, are suspect in the old
cataract-bearing animal and are under
investigation. Animal models with
increased or decreased antioxidant
protection for lens cells comprise
promising subjects to discern the role
of ROS in the development of ARC and
continue to be studied. The role of ARC
as a biomarker of global aging in the
body is an additional goal.
SESSION
BACKGROUND
This session is sponsored by the
Biotechnology and Biological
Sciences Research Council
(BBSRC) through the UK
SPARC Network for Ageing Research.
In recent years the UK has made
sustained efforts to establish a
dynamic research community focused
on the biology of aging. Over six
years the BBSRC has invested £9.2
million in 49 projects. These
projects have studied the
fundamental mechanisms of ageing at
the population, organism, tissue and
cell levels. As a result of this
activity many established
researchers have entered gerontology
and an outstanding group of young
scientists have been trained in
their labs. The symposium will
provide an opportunity to review
some of the data generated by these
programs and to meet some of the
researchers. Work on the aging of
the immune system and the aging of
muscle, skin and soft tissue will be
presented. Other speakers will
address the relationship between
oxidative stress and the aging of
simple organisms and how
psychological and biomechanical
parameters influence inclusive
design for older people.
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The Modification of IL-7
and the Reversal of
Thymic Atrophy in Aged
Mice |
Sian Hensen |
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Functional Effect of
Failure of Adaptive
Responses in Skeletal
Muscle During Aging |
Anne McArdle |
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Reconstructing Young and
Aged Skin |
Ian Kill |
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Analyzing the
Relationship Between
Oxidative Stress and
Aging in Drosophila |
Robert Saunders |
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Understanding Soft
Tissue Aging - the
Effect of Cyclical
Loading |
Roger Smith |
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Inclusive Design Tool
Based on Psychological
and Biomechanical
Functional Performance |
Bernie Conway |
SESSION SPEAKERS
Bernie Conway, PhD, Strathclyde University, UK
.jpg) Sian Henson, PhD,
Imperial College,
UK
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Dr Henson is a research
fellow in the Department of
Immunology and Molecular
Pathology at UCL, London.
After obtaining a first
class honours degree from
Southampton University in
Biochemistry in 1997 she
went on to complete a PhD in
Biochemistry at Imperial
College. Her post doctoral
work centred around the
reversal of thymic
atrophy, which is a key
event that leads to the
inefficient functioning of
the immune system with age,
and in particular the use of
IL-7 as an immunorestorative
agent. This work lead to the
patenting of a number of
novel IL-7 fusion proteins
that have the ability to
boost de novo T cell
generation by the thymus. Dr
Henson’s current research
interest is the role played
by inhibitory receptors
during aging. Dr Henson is
an
Executive Member of the
British Society for Research
on Ageing and is funded
by a Research into Ageing
Fellowship.
 Ian
R. Kill, PhD, Brunel
University,
UK
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Dr. Kill is a Senior
Lecturer in Human Cell
Biology in the Biosciences
Division of the School of
Health Sciences and Social
Care, Brunel University,
West London. He is Director
of the Centre for Cell and
Chromosome Biology and Head
of Research for Biosciences.
Dr. Kill obtained his D.
Phil from Sussex University
in 1999 then spent 7 years
at the University of Dundee
as a Post-Doctoral Fellow
before taking up his
appointment at Brunel
University. Dr. Kill is
interested in the
relationship between
cellular ageing and
organismal ageing. His
current research includes an
investigation into the cell
biology of Hutchinson
Guilford Progeria Syndrome
and the reconstruction of
young and aged skin in
vitro. Most recently, Dr
Kill has initiated a new
study into gender-specific
differences in lifespan
using a strain of killifish
with a 12 week lifespan, one
of nature’s shortest-lived
vertebrates.
Read more at:
www.brunel.ac.uk/about/acad/health/healthres/researchareas/ccbg/
 Anne McArdle, PhD,
University of
Liverpool, UK-
Dr. McArdle is a Reader in
the School of Clinical
Sciences at the University
of Liverpool, UK. Dr McArdle
is interested in the basic
processes by which cells
respond and adapt to stress
and damage, and in
particular, the role that
the age-related failure in
the stress response plays in
the increased susceptibility
of aged muscle to damage and
poor recovery from that
damage. Anne is an Executive
Member of the British
Society for Research on
Ageing and Editor of the
BSRA journal, Lifespan.
Anne was previously funded
by a Research into Ageing-funded
Fellowship and currently
holds a Programme Grant from
Research into Ageing
to study the basic
mechanisms of failure of the
stress response in skeletal
muscle. Anne is also funded
by Medical Research
Council and BBSRC
and is part of a
multi-centre NIA –
funded study with Professor
Faulkner (Michigan),
Professor Jackson
(Liverpool), Professor
Richardson and Dr van Remmen
(San Antonio) and Dr Csete
(Atlanta) where her role is
to examine the effect of
aberrant ROS production on
the ability of muscles to
produce stress proteins.
Read more at:
www.liv.ac.uk/clinicalsciences/root/division%20of%20metabolic%20&%20cellular%20medicine/research/cel.htm
 Robert Saunders, PhD,
The Open
University, UK -
Dr Saunders received his
first degree in Genetics
from the University of
Edinburgh (1982). His PhD,
on female sterile mutants of
Drosophila, was taken
in the Department of
Molecular Biology at the
University of Edinburgh
(1986). Since that time his
research interests have
focussed on the cell cycle
(1986-1994), genome analysis
(1989-2001) and the
relationship between
oxidative stress and ageing
(1999 to date). These
projects have all used
Drosophila as a model
system. From 1994 to 1999,
he held a Wellcome Trust
Senior Research Fellowship,
investigating chromosome
inversions in the malaria
mosquito Anopheles
gambiae. Dr Saunders is
a member of the BBSRC Genes
and Developmental Biology
Panel, and a member of the
MRC College of Experts.
Current Research Interests
Related to Ageing:
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Glutathione Biosynthesis, Oxidative
Stress and Ageing
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Glutamate cysteine ligase
-
Glutathione Synthetase
-
Oxidative stress and ageing
-
Werner's Helicase
Read more at:
http://www.open.ac.uk/personalpages/r.d.saunders/index.html
 Roger Smith,
VetMB,
PhD, DEO, DipECVS, MRCVS,
Royal
Veterinary College, UK -
Dr. Smith is currently
Professor of Equine
Orthopaedics at the Royal
Veterinary College. He
qualified as a veterinary
surgeon from Cambridge
University in 1987 and,
after 2 years in practice,
returned to academia to
undertake further clinical
training as a Resident in
Equine Studies at the Royal
Veterinary College.
Following his residency, he
undertook a 3 year research
project culminating in the
award of a PhD for his
studies on the extracellular
matrix of equine tendon. He
remained at the Royal
Veterinary College, first as
a Lecturer in Equine
Surgery, then as Senior
Lecturer in Equine Surgery
before his appointment to a
Professorship in December
2003. He holds the Diploma
of Equine Orthopaedics from
the Royal College of
Veterinary Surgeons, and is
both a Diplomate of the
European College of
Veterinary Surgeons and a
Royal College of Veterinary
Surgeons Specialist in
Equine Surgery. He
currently divides his time
equally between running a
specialist orthopaedic
service within the Royal
Veterinary College and
continuing to direct
research into equine tendon
disease. His main area of
research is understanding
the mechanisms of tendon
ageing but also has projects
investigating the
epidemiology of tendon
disease in the horse, the
development of a serological
assay for tendonitis, and
stem cell therapy for
tendons in conjunction with
a commercial company,
VetCell Bioscience Ltd.
Read more at:www.rvc.ac.uk/Research/Groups/Musculoskeletal/Index.cfm
Wish to contact any of the speakers or
comment on this session? Click here.
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ANNOUNCEMENTS |
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WELCOME TO OUR NEW AGE MEMBERS:
Rozlyn Krajcik, PhD, RPh - SCIENTIFIC
MEMBER - OFAS
Pierre Rioux,
PhD - SCIENTIFIC MEMBER
 Christopher Smelick, BS - SCIENTIFIC MEMBER
- Phase Bioscience. Chris is a pre-med
graduate of UNC Chapel Hill with B.S. in
biochemistry. He is currently doing a premedical
internship at a family practice in Chapel Hill.
His main current research interest is the
etiology of post-mitotic aging in the brain,
especially where mitochondrial dysfunction might
play a role in this. He is also very interested
in how biogerontological research relates to
contemporary medicine, i.e., how underlying
causes of aging are putatively causative in
leading causes of mortality. Chris runs
www.biologicalgerontology.com
If we
had omitted your name from this list of new
members,
please let us know.
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Click here to support AGE with $35 OR MORE
FOR
ITS 35 SUCCESSFUL YEARS! |
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Father of the Free Radical
Theory of Aging Still Going Strong at 90!
 MEDIA, Pa.,
Feb. 13 -- Denham Harman, MD, PhD, FACP, FAAA, and the
father of the free radical theory of aging, will turn 90
on Tuesday, February 14, 2006. But that won't stop
him from continuing to work each day as Professor
Emeritus at his office at the University of Nebraska
School of Medicine in Omaha, and to continue to point
out the importance of aging research for all of us.
Could it be the antioxidants?
Dr. Harman's theory that highly reactive molecules known as
free radicals may explain aging, and his research
indicating that antioxidants may retard aging and
age-related diseases, have probably influenced more
research on aging than any other theory to date.
Free radicals are made in the body mostly as unintended
side effects of metabolism, and can start chain
reactions of indiscriminate damage. But Harman
showed that feeding mice antioxidants could extend their lifespans by up to 45%.
Harman's immense contribution to biomedical aging research
has earned him international acclaim and repeated
nominations for the Nobel Prize. His work and
theories have also been the inspiration for much popular
interest in
ameliorating the effects of aging, helping to drive the
creation of a multi-billion dollar market in antioxidant
vitamins and nutrients and creating a basis for many
popular books on aging and life extension.
There is no doubt today that free radicals and oxidative
stress play major roles in diseases such as cancer and
heart disease as well as in aging itself, but when
Harman originally proposed his theory in 1954, his idea
was so "radical" and so novel that it required many
years to catch on.
Dr. Harman founded the American Aging Association in 1970 to
promote biomedical aging research aimed at understanding
and blunting aging and to disseminate the benefits of
this research to the scientific community, to
doctors, and to the general public. The
Association remains to this day the primary scientific
society for research on the biology of aging and the
application of knowledge about aging to improving the
lives of Americans.
Dr. Harman earned his B.S. and Ph.D. from the University of
California and his M.D. from Stanford University.
For more information, visit
www.cbsnews.com/stories/2003/06/13/health/main558663.shtml
Our
thanks to Dr. Greg Fahy for his contribution to this
material.
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GRANT
ANNOUNCEMENT:
Alzheimer's
Foundation Seeks Grant Applications for
Innovative Care Programs
Deadline: May 15, 2006
In its ongoing
mission to foster optimal care, the Alzheimer's
Foundation of America ( http://alzfdn.org/ ) is
accepting applications for the Brodsky Grant, an
annual grant recognizing an innovative program
or service that improves the lives of
individuals with Alzheimer's disease and related
illnesses, and their families.
For 2006, the second year that the grant will be
awarded, AFA has increased the amount of the
grant to $25,000. The Brodsky Grant will
again be presented to a new or existing program
that betters the lives of those affected by
dementia, and exemplifies innovativeness,
greatest need, and replication potential.
Programs could involve, but are not limited to,
hands-on care, delivery of social services,
cognitive stimulation, the arts, safety, and
training.
Only nonprofit organizations that are members of
AFA may apply. Organizations that join AFA prior
to the grant deadline are also eligible.
For more information about the Brodsky Grant
and/or AFA membership, see the AFA Web site.
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MEETING ANNOUNCEMENTS:
Have
a conference you want us to feature? Tell
us about it.
June 22 - 24, 2006
German Sociological Association (DGS),
Section on Ageing and Society Spring/Summer
Conference 2006
Vechta, Germany
European comparative research on ageing -
challenges and opportunities
www.sektion-altern.de/English/eindex.htm
July 23 - 28, 2006
Bregenz, Austria
Eighth International Symposium on
Neurobiology and Neuroendocrinology of Aging
Website:
neurobiology-and-neuroendocrinology-of-aging.org/
Contact: Dr Richard Falvo -
rfalvo@med.unc.edu
September 4-5 2006
Paris, France
Aging Research in
Immunology: The Impact of Genomics
Website:
www.arig.ac.at
October 13-15, 2006
Melbourne
Convention Centre, Australia
3rd
International Conference on Healthy Ageing and
Longevity
The primary aim of the Conference is to
stimulate discussion, debate, collaboration and
the exchange of ideas to create fertile ground
for forward thinking and decision making as the
baby-boom generation progresses through the age
structure.
Call for Abstracts Now Open.
Website:
http://www.longevity-international.com/default.asp
Contact
Noah.Weller@longevity-international.com
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